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Chowdhury, M., Azari, B

Statements Author contributions QW and ZC designed the study, searched the literature, and drafted the manuscript

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Lactated Ringers contains sodium, potassium, calcium, and lactate in a balance closer to natural plasma

In vitro, KYNA protects cortical neurons from reactive glia- and QA-induced atrophy, enhancing neurite complexity and synapse formation, indicating that increasing KYNA or inhibiting glial KP activity can mitigate excitotoxic and inflammatory neuronal damage [86]

148,149 On the other hand, there is evidence that CCK may play a key part in longer-term energy regulation by synergizing with the actions of leptin