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Distinct regulatory profile compared to sedative agents: Conventional sedatives typically enhance inhibitory neurotransmission directly, often suppressing neural activity broadly

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In humans, small intestinal epithelial cells convert Gln and glutamate to citrulline, which is then transported by the circulatory system to renal proximal tubular cells, where arginine is synthesized by arginine-succinate synthetase and arginine-succinate lyase in the urea cycle

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If supplements or fortified foods arent used, injections can restore levels