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Intermediate phase: weeks two through four More noticeable changes typically emerge during weeks two through four

Targeting transporter systems : As paracellular transport is tightly restricted, the BBB presents several transport mechanisms, including water and ion channels, solute carrier-mediated transport, and receptor-mediated transcytosis

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Zurlo et al., 2019)

Enhanced oral bioavailability, reduced irritation and increased hypolipidemic activity of self-assembled capsaicin prodrug nanoparticles