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Perry DK et al

Although the anti-Met macrocycles described above might be incapable of inducing dimerization, we reasoned that they might be rendered chemically amenable to induction of dimerization via an appropriate cross-linker (Fig

It is typically administered subcutaneously at 50100 mg daily in timed cycles, with noticeable energy and body-composition changes emerging within 38 weeks and side effects generally mild and transient

Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal [lower than normal], further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly