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Although there was a clear trend for a higher Firmicutes : Bacteroidetes ratio in the WD control group relative to the LD control group, this difference did not rise to the level of statistical significance

The compounds were intraperitoneally administered with the compound at 8 a.m

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This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases