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Thus, CHAC1 serves a dual role: it preserves mitochondrial function by ensuring a cysteine supply under nutrient stress, but it also facilitates ferroptosis by maintaining ETC activity, highlighting its potential as a therapeutic target in cancer treatment ( 4.4 Apoptosis CHAC1 is implicated in apoptosis, particularly in the context of ER stress and UPR

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& Schenker, S