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The FDA-approved labeling for naloxone has the following precaution about use during pregnancy: Naloxone should be used in pregnancy only if clearly needed. The administration of naloxone is appropriate, however, for pregnant patients who have serious signs of potential meperidine toxicity, such as respiratory depression, systemic hypotension, or unresponsiveness

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The blend is studied because its three components appear in tissue-repair, angiogenesis, and extracellular-matrix literature not because any human outcome has been established

[1] The synergistic effect of the blend may improve the overall flexibility and adjustability of the tissues following damage

Some users mistake water fluctuations for tissue changes