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Hyperpigmentation: 4% niacinamide reduces melasma severity, and 5% formulations show tone improvement when paired with antioxidants and tranexamic acid

Successful clinical validation would not only provide a new treatment option but also retrospectively validate the CXXC5-targeting mechanism in humans, which would increase confidence in PTD-DBM as well

Incorporating relaxation techniques, such as meditation or yoga, can be beneficial

[83] The most commonly reported adverse effects are typically mild and transient, often resolving with continued use or dose adjustments

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These estimates are general guidelines