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Studies suggest this approach can achieve tissue concentrations approaching injectable levels

Dynamic thiol/disulfide homeostasis plays an important role in oxidative stress, and an imbalance in this homeostasis may be indicative of oxidative stress 100

The observational studies ( n 4) included in this review supported associations of lower maternal B 12 and poorer cognitive functions in the child, whereas one RCT showed a beneficial effect of B 12 supplementation on offspring language abilities at 30 months but no effect at 9 months (Reference Behere, Deshmukh and Otiv125) (Table 3)

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Acknowledgements We would like to thank Brenda Guthrie Yoshinaga (Skybay Scientific Editing) for editing of the manuscript