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NAC : Has unique neuroprotective effects by regulating glutamate, the brains main excitatory neurotransmitter

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It's the molecule your mitochondria pass electrons through to make ATP (your cellular energy currency), and the molecule your sirtuins and PARP enzymes burn through when they do DNA repair

doi: 10.1007/978-3-319-75402-4_2

Improving the folding/aggregation changes observed with mutant ATXN3 has been successful with compounds such as 17-DMAG (an Hsp90 inhibitor and autophagy inducer), temsirolimus (a rapamycin analog that increases autophagy), cordycepin (autophagy inducer), and H1152 (a ROCK inhibitor shown to decrease levels of mutant ATXN3) [84, 90, 92, 172]