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Adv Drug Deliv Rev 181:114076
Furthermore, it is essential to elucidate the specific pathways of cross-organ migration of oral microbiota, their colonization conditions, and the regulatory details of their influence on gut-brain axis signaling, including immune factors, metabolites, and neurotransmitters
In the tooth loss model, serum metabolomics identified L-Asparagine as a key gut-derived metabolite that accumulated systemically and thereby further substantiating the mechanistic link along the oralgutbrain axis in vitro study (Ji et al., 2025)
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