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Despite these protective functions, it has been demonstrated that MTs are involved in tumorigenesis, cellular differentiation, drug resistance, and metabolic disorders such as diabetes and obesity, in which MTs expression is substantially deregulated in adipose tissue

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22 Hyperglycemia induces metabolic reprogramming in ECs, which is characterized by the accumulation of AGEs and the activation of the hexosamine, polyol, and PKC pathways

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