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It has been demonstrated in the CIA rat model that unrestricted Lard-rich Diet (LRD) feeding caused mild inflammation in healthy mice, but it can conditionally reduce inflammation in reloading endogenous PPAR- agonist fatty acids (128)

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up-regulation of ketone body pathway), antioxidant signalling (enhancement of glutathione metabolism pathways) and low-grade inflammation (down-regulation of the lipopolysaccharide biosynthesis pathway) (Reference Cignarella, Cantoni and Ghezzi99) and (v) changes in gut microbiota-associated metabolites (e.g

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J Biol Chem 270, 443850