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(1) Some peptides communicate directly with the brain or endocrine system, while others affect the immune or digestive systems

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The H2S-dependent BP-reducing effect is thought to be primarily mediated through sulfhydration of ATP-sensitive potassium (KATP) channels, which in turn leads to voltage-sensitive channel opening and relaxation of vascular smooth muscle cells

Researchers have investigated tirzepatide in preclinical and clinical settings related to incretin signaling, glucose regulation, and energy balance