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Published animal studies using BPC-157, including those extending across multiple weeks of daily administration, have not documented tumor formation or accelerated malignant growth as an observed outcome

FEBS Lett 584:889897 Kangasjrvi S, Lepist A, Hnnikinen K, Piippo M, Luomala E-M, Aro E-M, Rintamki E (2008) Diverse roles for chloroplast stromal and thylakoid-bound ascorbate peroxidases in plant stress responses

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Because substitution with glycine (G) may disrupt the FHA domain conformation, we additionally generated alanine (A) substitutions (K265A, K301A, E365A, and K265A/K301A)