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Furthermore, pharmacokinetic heterogeneity across patient populations, driven by genetic polymorphisms in metabolic enzymes or variable tumor microenvironment conditions, necessitates personalized dosing strategies yet remains underexplored in clinical settings [164]

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538 UPS-targeted therapies in autoimmune diseases MDM2 inhibition MDM2, an E3 ligase best known for regulating p53 stability, also contributes to immune dysregulation

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Possible side effects include[10]: Bloating or abdominal discomfort Nausea or vomiting Diarrhea Headaches Dizziness or feeling lightheaded Flushing or low blood pressure Rare but serious reactions, such as allergic responses or irregular heartbeat, have been reported, especially in individuals with heart conditions