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[5] ^ Terashima, Tomoya, Hideto Kojima, Hiroshi Urabe, Isamu Yamakawa, Nobuhiro Ogawa, Hiromichi Kawai, Lawrence Chan, and Hiroshi Maegawa

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Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions

One of its remarkable features is the presence of a sticky sulfur chemical group that collects and neutralizes harmful molecules floating in the body

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These hexapeptides showed appreciable GH-releasing potency but co-stimulated adrenocorticotropic hormone (ACTH), cortisol, and prolactin, a lack of selectivity that would become the central design problem for later compounds in the class