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This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment

It may or may not be reversible

By combining these components, GLOW provides a consistent platform to investigate collagen-related signaling, soft-tissue remodeling, and inflammation-balance pathways in preclinical and in-vitro models

27 FatimaA.AndrabiS.WolfG.EngelmannM.SpinaM

We found that CD36 was particularly expressed in the PDX coming from TNBC of the LAR subtype, which is known to be more sensitive to ferroptosis [22]

Biomarkers we test for include CBC, CMP, Testoserone, Prolactin, PSA, SHBG, and Estradiol