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Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

Temporarily depleting microglia with liposome-encapsulated clodronate injected intracerebrally lasted 3 days with reappearance of microglia after 5 days

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doi: 10.1038/s41598-020-58701-4 38

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Additionally, ferroptotic characteristic changes of mitochondria were observed in IMQ- treated mice ear, suggesting ferroptosis occurrence in IMQ-induced psoriasiform dermatitis