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The phenolic hydroxyl group contributes additional hydrogen bonding capacity, while the aliphatic chain increases hydrophobic character relative to shorter peptide analogues

Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% over 48 weeks results that exceeded those seen with currently approved agents at the time of publication

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doi: 10.3171/2012.2.JNS111360

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Preclinical Findings (Animal & Cellular) Adipose NNMT inhibition increases energy expenditure and reduces fat mass