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628 Interestingly, low concentrations of TNF- can induce hepatocyte proliferation by activating YAP, whereas high concentrations trigger cell death by inducing phosphorylation and inactivation of YAP following APAP treatment

[DOI] [PubMed] [Google Scholar] Kilberg MS

In addition, the caffeine opens up the gallbladder ducts facilitating bile to flow even more

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In vitiligo context, it may be part of a broader metabolic program that promotes maintenance over growth by mediating an adaptive response directed towards rebalancing metabolic supply