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In another study, 1000 mg/kg of glutamine showed a significant increase in IL-1 and IL-6 levels after 15 days

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However, symptoms such as pain, stiffness, or swelling may be minimal or absent

10.3389/fendo.2023.1085799 140 WangX.LeiX

In agreement with prior literature [35], this result suggests that GSH is not stable in plasma at 4 o C, and thus samples should not be stored at this temperature

To address this, researchers have developed strategies such as local administration, targeting ligands on CPPs, or using activatable CPPs that penetrate only under specific biological stimuli