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Additionally, wound-associated microbiota influence TLR signaling dynamics by producing metabolites and structural components that either activate or inhibit specific TLRs, shaping the local immune microenvironment [37]

Smoking and drinking also negatively impact blood circulation, depriving the skin of oxygen and essential nutrients, making it more prone to pigmentation issues

Systematic capture of dosing patterns, formulation source, route of administration, and standardized clinical outcomes may be more informative than continued reliance on heterogeneous mechanistic studies

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Published online 16 November 2024