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Journal of pharmacological sciences , 108 (1), 7-17

Mild therapeutic hypothermia in clinical settings is typically maintained at 3234C, while moderate hypothermia may reach 2832C

14 As for its mechanism of action, it is known to act by reducing the expression of pro-inflammatory cytokines through the NF-B pathway and inhibiting the expression of COX-2, 5-lipooxygenase (5-LO) and PGE2 synthesis, resulting in a marked reduction in pain and an improvement in joint function

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