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doi: 10.1021/acs.jafc.9b07670 103
Because of these roles, B12 is fundamental to: Red blood cell formation : Preventing macrocytic anemia and ensuring efficient oxygen transport Myelin synthesis : Maintaining the protective sheath around nerve fibers for rapid signal transmission DNA replication and repair : Supporting healthy cell division across all tissues, particularly the gastrointestinal lining and bone marrow Without adequate B12, you may experience fatigue, neurological symptoms, and hematologic problems that progressively worsen over time
Overall Adverse Event Rates Dose Group Any Adverse Event (%) GI Adverse Events (%) Discontinuation Due to AE (%) Placebo 72.1% 32.6% 0% 1 mg 88.6% 48.6% 2.9% 4 mg (escalated) 88.6% 60.0% 5.7% 4 mg (single dose) 90.9% 63.6% 6.1% 8 mg (escalated) 87.5% 57.5% 5.0% 8 mg (single dose) 88.6% 62.9% 5.7% 12 mg (escalated) 97.2% 66.7% 8.3% Source: Jastreboff AM, Kaplan LM, Fras JP, et al
619 Eliapixant in patients with DNP did not translate to any relevant improvement in different pain intensity outcomes compared with placebo in phase 2a of the PUCCINI study
