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Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis

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Their potential mechanism of action would be the inhibition of prostaglandins and cytokines, including endothelin 1 and granulocyte macrophage colony-stimulating factor (GM-CSF), which are the main stimulators of melanin production (Menter, 2004)

However, there are also some host factors, such as polymorphism of the IL-1, which influences gastric acid secretion, or polymorphism of the CYP2C19, which is the main enzyme metabolizing PPI (proton pump inhibitor), that are associated with the risk of gastric cancer development (Uotani et al

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doi: 10.1042/bj20100409