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In some specific research protocols, alternatives are used: Sterile water for injection (WFI) , when the entire contents of the vial are used at once and a preservative is not needed Physiological saline (0.9% NaCl) , in some applications requiring an isotonic environment Acidic solvents (e.g

[12] Wakabayashi, C., Numakawa, T., Ninomiya, M., Chiba, S., & Kunugi, H

OCLC 276871036

In 2026, trials must be designed for external volatility, with greater focus on milestone discipline, funding resilience, and regulatory foresight