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Determine the optimal cleavage site and chemical structure based on target enzyme characteristics and drug properties

They work through entirely different mechanisms than copper peptides

10.1016/j.taap.2010.04.005 60 LvS.WuN.WangQ.YangL

Although the mechanism is still unclear, immune cells such as T cells, B cells, and macrophages have been implicated in the pathogenesis of UC, as well as several cytokines and chemokines that regulate immune responses

In the present study, the cecal microbiome differed significantly across treatment groups, despite tightly controlling for several variables known to alter the microbiome in rodents