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Karin, "ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development", Cancer cell , 2014 , 26 (3), 331

Semaglutide acts on one gut hormone (GLP-1), while tirzepatide acts on two (GLP-1 and GIP)

Indirect effects The hypoxia-induced acidic microenvironment of tumors can affect drug efficacy 45 , and promote the phenotypic expression of breast cancer stem cells (CSCs) and the acquisition of MDR in breast cancer

And its actually a natural gastric peptide that is produced

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McCracken JL, Veeranki SP, Ameredes BT, Calhoun WJ