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Figure 1 Metabolism of Glutamine and Glutamate in Intestinal Epithelial Cells and Immune Cells: Their Function as Energy Substrate and Protein Precursors It is well-established that glutamine and glutamate are important energy substrates for intestinal epithelial cells (IECs) and immune cells, especially during periods of rapid growth (86)

They can inhibit therapeutic efficacy by reducing intracellular concentration, decreasing its bioavailability, and reducing the transition through the bloodbrain barrier (BBB)

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Sarafraz-Yazdi, E., Adler, V., Bowne, W., Sookraj, K., North, A., Niharny, P., & Michl, J

CASA depletion reduces adaptive capacity and accelerates age-related pathology