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Based on these data, the FDA approved tesamorelin (marketed as EGRIFTA) for the reduction of excess abdominal fat in HIVassociated lipodystrophy, not as a general weightloss drug for the wider population. Tesamorelin Risks and Considerations Like all hormonemodulating therapies, tesamorelin carries potential risks, including fluid retention, joint pain, injectionsite reactions, and effects on glucose metabolism in susceptible patients

The peptide works best as part of a comprehensive approach including proper nutrition, regular exercise, and lifestyle optimization rather than as a standalone intervention

Low: P = 0.021

A careful review can determine whether B12 alone is enough or whether a broader nutrient strategy is more appropriate

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