In the reconstruction system comprised of the neuronal synaptic proteins or airway homologs [including synaptosomal-associated protein of 23 kDa (SNAP-23), syntaxin-3 (Stx3), Syt2, vesicle-associated membrane protein 8 (VAMP-8), mammalian homolog of Caenorhabditis elegans uncoordinated gene 13 (Munc13-2), and Munc18-2], the stapled peptide SP9 has exhibited strong suppression to fusion triggered by Ca 2+ at physiological Ca 2+ concentrations, whereas the non-stapled peptide penetratin (PEN)-P9-sulfo cyanine3 (Cy3) did not show any inhibitory effects at the same concentration, suggesting the specificity of the stapled peptide SP9 (Figure 7F)
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Available online at: (Accessed May 30, 2026)
