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Because H 2 S and Fe 2+ are abundant in hydrothermal environments, primitive organisms likely extracted two electrons of reducing power from oxidation of H 2 S, which then coupled with Fe 2+ , yielding pyrite (FeS 2 )[20]

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Moreover, rats treated with 1% neohesperidin dihydrochalcone for 1 month showed reduced amygdala neuroinflammation via suppression of cAMP/PKA pathway activity, restoration of cortical 5-HT, DA, and NE levels, and reversal of anxiety- and depression-like behaviors (Jiang et al., 2023)