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Damoiseaux, J.S

The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway

Consequently, it helps to eliminate the free radicals which buffers the oxidative stress

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Succinyl-CoA is generated under the catalysis of succinyl-coenzyme A ligase (SUCL), which consists of the -subunit encoded by SUCLG1 and the -subunit encoded by SUCLA2, formed from ATP or SUCLG2, formed from GTP [78]

Along with AMPK protein reduction, YBX1 expression was also decreased in shGDH1 cells and rescued by exogenous -KG (Fig