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1) Core toxicology: a narrow physiologic buffer at the top of the therapeutic range Metabolic pathway: ~9095% is detoxified via glucuronidation and sulfation

However, no morphological changes were observed in neutrophils in T2D subjects [35]

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Results from the co-treatment with Fer1, a ferroptosis inhibitor, and ZVAD, an apoptosis inhibitor, indicate that RSL3 effects were reversed by Fer1 but not by anti-apoptotic ZVAD