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Adipose tissue-derived free fatty acids (FFAs) impair renal urate excretion via URAT1 upregulation, while hyperuricemia reciprocally induces insulin resistance and endothelial dysfunction through AMPK inhibition and oxidative stress (Xu et al., 2015)

Trends Pharmacol Sci 23:299302 Mosharov E, Cranford MR, Banerjee R (2000) The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes

Notably, these findings were concomitant with a decline in ATP levels and the inhibition of oxidative phosphorylation

The Depth of Chemical Time and the Power of Enzymes as Catalysts

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Biomedicines 10 , 3111 (2022)