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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

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MOTS-c has been shown to prevent muscle atrophy by reducing myostatin levels, a negative regulator of muscle mass

Int J Mol Sci (2023) 24(19):14815

HCM and C2C12 cells were stained with TMRM at an ultimate concentration of 200 nmol/L

However, clinical trials show that Ozempic generally leads to greater overall weight loss, while phentermine tends to work faster initially