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It is proposed that the dimeric KEAP1 captures NRF2 first through the ETGE motif, which has 100-fold more affinity to KEAP1, followed by DLG motif docking onto the other Kelch repeat domain

References: Bolke et al

WZ prepared and wrote the original draft and was responsible for supervision, project administration and funding acquisition

Remethylation: Hcy turns back into methionine with folate, MTHFR, and vitamin B12

Correlation between the composition of green Arabica coffee beans and the sensory quality of coffee brews

A study showed that using high-energy picosecond 1064nm laser with large light spots to treat melasma, once a week for 10-20 times, the effective rate can reach 73.33% (8 cases were basically cured, 25 cases showed significant improvement, 11 cases improved, and only 1 case was ineffective)