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Excessively rapid reductions in blood pressure can cause uncontrollable hypotension and hypoperfusion, which has historically resulted in permanent cortical blindness (Morton and Hickey-Dwyer, 1992), myocardial infarction (Messerli and Eslava, 2008), and devastating ischemic strokes (Schwartz et al, 1990
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Factors such as blood dilution, ischemiareperfusion injury, and the release of inflammatory mediators further complicate recovery
