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When drawing solution for research, do so efficiently and re-cap the vial promptly

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These findings appear to be a result of disease and not other variables such as age or biological sex, as no significant difference in biological sex distribution within the cohort was found (Students t Test, p = 0.98) (Supplementary Data 1)

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Finally, given that clinician-driven dose changes were allowed for participants on both IR-Tac and LCPT, some participants may not have been at steady state on day 7 or 14, which may have underestimated t 1/2eff

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