doi: 10.3389/fendo.2023.1133000 Received 28 December 2022 Accepted 13 March 2023 Published 24 March 2023 Volume 14 - 2023 Edited by Silvia Martina Ferrari, University of Pisa, Italy Reviewed by Sabrina Rosaria Paparo, University of Pisa, Italy
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Immune System Support: Glutathione keeps white blood cells active, which is essential for preventing infections and diseases
Upon Trx redox switch from holdase to foldase function, alternative targeting of PGL3 (and G6PD1) to peroxisomes is achieved (Hlscher et al., Stress or developmental change activates glycolysis and the OPPP, which provides NADPH for oxidative bursts at the plasma membrane (Pugin et al., ) is extruded into the acidic apoplast of plant cells, where it is converted to hydrogen peroxide (H 2 O 2 ), and may enter the cytosol via aquaporins to initiate redox signaling (Mittler, via NADPH-dependent glutathione reductase and thus also profits from OPPP activation under stress
Dissecting acute drug-induced hepatotoxicity and therapeutic responses of steatotic liver disease using primary mouse liver and blood cells in a Liver-On-A-Chip model
