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CHE also triggered the mitochondrial intrinsic pathway by upregulating the expression of APAF1, cleaved-caspase3,9, and cleaved-PARP in HeLa cells (T

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They are also checking for insulin resistance, hormone patterns, and other clues that might respond better to a GLP-1-only or a dual-incretin approach

However, its benefits for fat burning, aerobic performance, or endurance remain inconsistent and often require conditions (e.g., high carbohydrate intake) that may not align with typical athletic nutrition strategies