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GLS1 levels reportedly increase following mTOR inhibition 57,58 , and we have previously proposed the combination of a GLS inhibitor and aspirin, an mTOR inhibitor, for the treatment of PIK3CA -MT colorectal cancer

Psychiatry 26, 54815503

However, further research in additional mouse models is necessary to understand the comprehensive effects of such molecular drugs on NAFLD [73]

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Experimental observations include reduced severity of hemorrhagic events, improved cardiac rhythm stability, and attenuation of injury in organs such as the lungs, liver, kidneys, and gastrointestinal tract.(24) These outcomes appear to be linked to preservation of vascular integrity and improved microcirculatory function, underscoring its broad organ-supportive activity within preclinical research settings

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