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Cristofori et al., 2005), which remains too invasive for concussion patients

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In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyl tetrahydrofolate, resulting in functional folate deficiency

FDAs nonclinical assessment described sleep-related pharmacology as involving opioid-dependent mechanisms even though DSIP does not appear to bind directly to conventional opioid receptors