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These substances can activate key pro-inflammatory signaling pathways such as nuclear factor kappa B (NF-B), thereby inducing the gene transcription and protein secretion of extracellular matrix (ECM) degrading enzymes like matrix metalloproteinase 13 (MMP13) and A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS5) (Miao et al., 2022
Regulation of apoptosis by protein S-nitrosylation
PMID: 28853742
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It now displays the core traits of a criminal insurgency, including integrated territorial control, expanded military capacity, and a consistent doctrine of retaliation against state pressure
