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BPC-157 has been observed to downregulate pro-inflammatory cytokines and protect against NSAID-induced tissue damage, while TB-500 may modulate macrophage activity and support immune cell migration

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Some physicians use BPC-157 only during the GLP-1 titration window (the first 3 to 4 months when GI side effects are highest), then taper off once the maintenance dose is stable and well-tolerated

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