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Treatment typically involves three sessions spaced four to six weeks apart, followed by maintenance sessions every six to twelve months

Jaggupilli A, Ly S, Nguyen K, et al

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The overall lower total organic content for the FA-conjugated material (30%) compared with the non-conjugated drug-loaded SBA-15 (50%) implies that conjugation reduced the amount of physically adsorbed (free) drug for example by replacing weakly adsorbed drug with covalently tethered folic-aciddrug species or by additional washing steps removing unbound drug

Brain Res 237 , 164171 (2013)