These authors also reported that ZnT8 depletion may trigger the formation of atypical insulin-zinc secretory granules [133, 134]
Cancer Res 50:245251 Willett W, Stampfer MJ (1986) Total energy intake: implications for epidemiologic analyses
1f), and rescue by xCT overexpression was countermanded by the xCT inhibitor erastin (Extended Data Fig
Product pages, research category pages, and available analytical documentation provide compound-specific information where available
This auto-oxidation process generates toxic reactive oxygen species (ROS), quinones, and free radicals that damage intracellular organelles, deplete cellular glutathione, and ultimately trigger apoptotic cell death (Lohr et al., 2014
10.1089/neu.2007.0266 41