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In LO2 cells, compared with control group, the alcohol-induced LO2 cells in model group revealed that ACC, CHOP, Caspase-3 and Cleaved caspase-3 significantly increased, and pACC and PPAR- significantly decreased in contrast (Figure 8A and 8B)

32 Recent studies revealed that gender specific genomic differences in MDD patients, the downregulation of the MDD-related gene Dusp6 in females leads to an increased susceptibility to stress, but this expression is not present in male mice

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doi: 10.1016/j.cell.2011.02.013

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