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Cellular senescence was assessed by measuring senescence-associated -galactosidase (SA--gal) activity using a commercial staining kit

Importantly, resting extracellular polyamine concentrations are lower than needed to robustly exert NMDA modulatory effects, and NMDA receptor activation triggers extracellular Spd and Spm release in the striatum (Fage et al., 1992

Understanding why spotting happens helps women distinguish between normal perimenopausal changes and symptoms that need medical attention

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Some studies suggest interaction with inflammatory signaling markers in experimental models, though conclusions remain preliminary